What to expect on Actemra for Giant Cell Arteritis (GCA)

STARTING IV INFUSIONS OF ACTEMRA FOR GIANT CELL ARTERITIS (GCA) TREATMENT

Before starting treatment, your healthcare provider should review the ACTEMRA Medication Guide with you. He or she should discuss how treatment will work and any possible side effects you may experience.

Before treatment

Here are some tips for your first IV infusion appointment:

Arrive a little bit early to take care of any paperwork
Bring your insurance card every time you get an IV infusion
Wear comfortable clothing, if possible
Your IV infusion will last about 1 hour. You may want to bring music, a book, or some games to help you pass the time
Write down any questions you have for your healthcare provider or IV infusion specialist. Since they’ll be around to monitor you, this is a great time to get answers

Weighing In

If you are taking ACTEMRA as an IV infusion, the dose is based on your weight, so before every infusion, you’ll be weighed.
If your weight changes, you and your healthcare provider will decide if a change in dose is necessary.

During your IV infusion

Monitoring

A healthcare provider or nurse should always be on hand during your ACTEMRA IV infusion to monitor you and to respond to any reactions and answer any questions you may have. It’s important to pay close attention to how you’re feeling during and after an IV infusion. ACTEMRA may lead to serious allergic reactions, including death, which may happen even if they have not happened before. Let your healthcare provider or nurse know if you’re experiencing:

Shortness of breath or trouble breathing
Swelling of lips, tongue, or face
Chest pain
Feeling dizzy or faint
Moderate or severe abdominal pain or vomiting

After your IV infusion

Note how you’re feeling after each ACTEMRA IV infusion. Tell your healthcare provider or nurse right away if you’re experiencing any reactions during or after treatment.

Blood tests

Before you start on ACTEMRA IV infusions, your healthcare provider will do a variety of blood tests. The chart below shows how often these tests will occur after you start treatment.

Liver function, neutrophil count, and platelet count

ACTEMRA Patient Support Line

Have questions about ACTEMRA?

Call 1-800-228-3672 to talk with a team member about ACTEMRA.

Financial
Support

You may qualify for help paying for ACTEMRA. Learn more about your options.

Next Page: Tips for Living With GCA

A biologic is a type of medicine developed using processes that are similar to what happens in your body naturally. Biologics can be used to interact with certain parts of your body, like your immune system. They can also fight inflammation in certain diseases, like GCA.
An inflammation of the blood vessels. The cause is often unknown.
When a part of the body becomes swollen and painful.
A flare is a sudden worsening of your disease. It can happen after you haven’t experienced symptoms for a long time. It’s also known as a relapse.
A chemical messenger that tells the immune system to attack harmful bacteria and viruses. When your body produces too much IL-6, it causes the immune system to attack healthy cells.
A decrease or disappearance in signs and symptoms.
Under the skin.
A sample of cells taken from the body in order to examine them more closely. A healthcare professional will recommend a biopsy when a test suggests an area of tissue in the body isn’t normal.
A genetic predisposition means that a person may be more likely to develop a disease based on their genes. However, they may not see any symptoms unless something in the environment triggers the disease.
Steroids, including cortisone and prednisone, are a type of medicine used temporarily to reduce inflammation.
Biologics, a type of DMARD, are a class of arthritis treatments designed to target your immune system.
The immune system is a complex network of organs and cells that protects the body from foreign substances such as bacteria, fungi, and viruses.

INDICATIONS

What does ACTEMRA treat?

ACTEMRA is a prescription medicine called an interleukin-6 (IL-6) receptor antagonist.

ACTEMRA is used:

To treat adults with moderately to severely active rheumatoid arthritis (RA) after at least one other medicine called a disease modifying antirheumatic drug (DMARD) has been used and did not work well
To treat adults with giant cell arteritis (GCA)
To treat patients with active polyarticular juvenile idiopathic arthritis (PJIA) 2 years of age and older
To treat patients with active systemic juvenile idiopathic arthritis (SJIA) 2 years of age and older
For slowing the rate of decline in lung function in adults with systemic sclerosis-associated interstitial lung disease (SSc-ILD) (also known as scleroderma-associated ILD).
To treat hospitalized adults with coronavirus disease 2019 (COVID-19) receiving systemic corticosteroids and requiring supplemental oxygen or mechanical ventilation.
ACTEMRA is not approved for subcutaneous use in people with COVID-19.

It is not known if ACTEMRA is safe and effective in children with PJIA or SJIA under 2 years of age or in children with conditions other than PJIA or SJIA.

ACTEMRA can cause serious side effects

Serious Infections

ACTEMRA changes the way your immune system works. This can make you more likely to get infections or make any current infection worse. Some people have serious infections while taking ACTEMRA, including tuberculosis (TB), and infections caused by bacteria, fungi, or viruses that can spread throughout the body. Some people have died from these infections. Your healthcare provider should assess you for TB before starting and during treatment with ACTEMRA (except if you have COVID-19).

Before starting ACTEMRA, tell your healthcare provider if you have:

an infection, think you may have an infection, are being treated for an infection, or get a lot of infections that return. Symptoms of an infection, with or without a fever, include sweating or chills; shortness of breath; warm, red or painful skin or sores on your body; feeling very tired; muscle aches; blood in phlegm; diarrhea or stomach pain; cough; weight loss; burning when you urinate or urinating more than normal
any of the following conditions that may give you a higher chance of getting infections: diabetes, HIV, or a weak immune system
tuberculosis (TB), or have been in close contact with someone with TB
live or have lived, or have traveled to certain parts of the United States where there is an increased chance of getting fungal infections. These parts include the Ohio and Mississippi River valleys and the Southwest
hepatitis B or have had hepatitis B

If you have COVID-19, your healthcare provider should monitor you for signs and symptoms of new infections during and after treatment with ACTEMRA.

Who should not take ACTEMRA?

Do not take ACTEMRA if you are allergic to tocilizumab, or any of the ingredients in ACTEMRA.

Be sure to talk to your healthcare provider if you see any signs of these serious side effects:

Tears (perforation) of the Stomach or Intestines

If you have diverticulitis (inflammation in parts of the large intestine), talk to your healthcare provider before taking ACTEMRA. Some people taking ACTEMRA may develop a hole in the wall of their stomach or intestines (also known as a perforation). This happens most often in people who also take nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, or methotrexate.

Tell your healthcare provider right away if you see any of these side effects: fever, stomach-area pain that does not go away, or if you see a change in your bowel habits.

Liver problems (Hepatotoxicity)

Some people have experienced serious life-threatening liver problems, which required liver transplant or led to death. Your healthcare provider may tell you to stop taking ACTEMRA if you develop new or worsening liver problems during treatment with ACTEMRA. Tell your healthcare provider right away if you have any of the following symptoms:

feeling tired (fatigue)
lack of appetite for several days or longer (anorexia)
yellowing of your skin or the whites of your eyes (jaundice)
abdominal swelling and pain on the right side of the stomach-area
light colored stools
weakness
nausea and vomiting
confusion
dark “tea-colored” urine

Changes in Blood Test Results

Your healthcare provider should do blood tests before you start receiving ACTEMRA. If you have rheumatoid arthritis (RA) or giant cell arteritis (GCA), or systemic sclerosis-interstitial lung disease (SSc-ILD) your healthcare provider should do blood tests 4 to 8 weeks after you start receiving ACTEMRA for the first 6 months and then every 3 months after that. If you have polyarticular juvenile idiopathic arthritis (PJIA) you will have blood tests done every 4 to 8 weeks during treatment. If you have systemic juvenile idiopathic arthritis (SJIA) you will have blood tests done every 2 to 4 weeks during treatment. These blood tests are to check for the following side effects of ACTEMRA:

Low neutrophil count: neutrophils are white blood cells that help the body fight infection
Low platelet count: platelets are blood cells that help with clotting, which stops bleeding
Increase in liver function test levels
Increase in blood cholesterol levels: your cholesterol levels should be checked 4 to 8 weeks after you start receiving ACTEMRA.

Your healthcare provider will determine how often you will have follow-up blood tests. Make sure you get all your follow-up blood tests done as ordered by your healthcare provider.

You should not receive ACTEMRA if your neutrophil and platelet counts are too low or your liver function test levels are too high. Changes in blood test results may cause your healthcare provider to stop your ACTEMRA treatment for a time or change your dose.

Cancer

ACTEMRA may increase your risk of certain cancers by changing the way your immune system works.

Hepatitis B Infection

If you have or are a carrier of the hepatitis B virus (a virus that affects the liver), the virus may become active while you use ACTEMRA. Your healthcare provider may do blood tests before you start treatment with ACTEMRA and while you are using ACTEMRA. Tell your healthcare provider if you have any signs of these symptoms:

feel very tired
skin or eyes look yellow
little or no appetite
vomiting
clay-colored bowel movements
fevers
chills
stomach discomfort
muscle aches
dark urine
skin rash

Serious Allergic Reactions

Serious allergic reactions, including death, can happen with ACTEMRA. These reactions can happen with any infusion or injection of ACTEMRA, even if they did not occur with an earlier infusion or injection. Tell your healthcare provider before your next dose if you had hives, rash or flushing after your injection.

Contact 911 immediately, as well as your healthcare provider, if you experience any of these reactions:

shortness of breath or trouble breathing
swelling of the lips, tongue, or face
chest pain
feeling dizzy or faint
moderate or severe abdominal pain or vomiting

Nervous System Problems

While rare, Multiple Sclerosis has been diagnosed in people who take ACTEMRA. It is not known what effect ACTEMRA may have on some nervous system disorders.

What should I tell my healthcare provider before receiving ACTEMRA?

ACTEMRA may not be right for you. Before receiving ACTEMRA, tell your healthcare provider if you:

have an infection
have liver problems
have any stomach-area (abdominal) pain or been diagnosed with diverticulitis or ulcers in your stomach or intestines
have had a reaction to tocilizumab or any of the ingredients in ACTEMRA before
have or had a condition that affects your nervous system, such as multiple sclerosis
have recently received or are scheduled to receive a vaccine
plan to have surgery or a medical procedure
have any other medical conditions
plan to become pregnant or are pregnant. It is not known if ACTEMRA will harm your unborn baby.
plan to breast-feed or are breast-feeding. You and your healthcare provider should decide if you will take ACTEMRA or breast-feed. You should not do both.
are taking any medications, including prescription and nonprescription medicines, vitamins, and herbal supplements.

The most common side effects of ACTEMRA include:

upper respiratory tract infections (common cold, sinus infections)
headache
increased blood pressure (hypertension)
injection site reactions

ACTEMRA & Pregnancy

Tell your healthcare provider if you are planning to become pregnant, are pregnant, plan to breast-feed, or are breast-feeding. You and your healthcare provider should decide if you will take ACTEMRA or breast-feed. You should not do both. If you are pregnant and taking ACTEMRA, join the pregnancy registry. The purpose of this registry is to check the health of the pregnant mother and her baby. To learn more, call 1-877-311-8972 or talk to your healthcare provider to register.

Tell your healthcare provider if you have any side effects. You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects to Genentech at 1-888-835-2555.

Please see full Prescribing Information and the Medication Guide, including Serious Side Effects, for more Important Safety Information.